MRI measurement of the canine auditory pathways and relationship with brainstem auditory evoked responses

R. Poma; H. Chambers; R. C. da Costa; N. B. Konyer; S. Nykamp; H. Dobson; N. W. Milgram

doi:10.1055/s-0037-1617367

Veterinary and Comparative Orthopaedics and Traumatology, Table of Contents

Vet Comp Orthop Traumatol 2008; 21(03): 238-242
DOI: 10.1055/s-0037-1617367

Original Research

Schattauer GmbH

MRI measurement of the canine auditory pathways and relationship with brainstem auditory evoked responses

R. Poma

¹Department of Clinical Studies, University of Guelph, Guelph, Ontario, Canada

,

H. Chambers

²Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada

,

R. C. da Costa

³Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA

,

N. B. Konyer

⁴Brain-body Institute, St. Joseph Health Care, Hamilton, Ontario, Canada

,

S. Nykamp

¹Department of Clinical Studies, University of Guelph, Guelph, Ontario, Canada

,

H. Dobson

¹Department of Clinical Studies, University of Guelph, Guelph, Ontario, Canada

,

N. W. Milgram

⁵CanCog Technologies Inc., Toronto, Ontario, Canada

› Author Affiliations

Abstract

Summary

The objective of this study was to determine direct measurements of auditory pathways by magnetic resonance imaging (MRI) during the growth period of healthy Beagles, and to discover how canine brainstem auditory evoked response (BAER) latencies vary in relation to these MRI measurements. Eighty healthy Beagles were tested at eight, 16 and 52 weeks of age (stages 1, 2, 3, respectively) with BAER and brain MRI. The BAER interpeak latency (IPL) II-V and brain MRI neural generators of BAER waves II and V were identified. A linear distance was calculated in millimeters in order to determine the approximate length of auditory pathways. Sensory nerve conduction velocity (SNCV) of the auditory pathway between peak II and peak V was calculated for each group. A significant difference was observed between brain MRI distances among the three stages. Mean BAER IPL II-V were not significantly different between the three stages. The progressive growth of the skull and brain witnessed by the progressive increased distance of the MRI auditory pathways between peak II and peak V was not associated with a progressive maturation of the BAER IPL II-V. The SNCV of the auditory pathway between peak II and peak V was 6.14 m/sec for group 1; 6.76 m/sec for group 2; and 7.32 m/sec for group 3.

Keywords

Auditory pathways - canine - magnetic Resonance Imaging - brainstem auditory evoked response (BAER)

Full Text

References

References
1 Sims MH, Moore RE. Auditory-evoked response in the clinically normal dog: early latency components.. Am J Vet Res 1984; 45: 2019-2027.
2 Sims MH. Electrodiagnostic evaluation of auditory function.. Vet Clin North Am Small Anim Pract 1988; 18: 913-944.
3 Morgan JL, Coulter DB, Marshall AE. Effects of neomycin on the waveform of auditory-evoked brain stem potentials in dogs.. Am J Vet Res 1980; 41: 1077-1081.
4 Goff WR, Allison T, Lyons W. Origins of short latency auditory evoked potentials in man.. In: Desmedt, JE (ed): Progress in clinical neurophysiology, vol. 2. Basel, Switzerland, S Karger, Press, 1977: 45-57.
5 Stockard JJ. Rossiter V Clinical and pathological correlates of brainstem auditory response abnormalities.. Neurology 1977; 27: 316-325.
6 Starr A, Hamilton AE. Correlation between confirmed sites of neurological lesions and abnormalities of far-filed auditory brain stem responses.. Electroencephalogr Clin Neurophysiol 1976; 41: 595-608.
7 Achor LJ, Starr A. Auditory brain stem responses in the cat. II. Effects of lesions.. Electroencephalogr Clin Neurophysiol 1980; 48: 174-190.
8 Gardij BS. Jr. The use of kainic acid for studying the origins of scalp-recorded auditory brainstem responses in the guinea pig.. Neurosci Lett 1981; 26: 143-149.
9 Achor LJ, Starr A. Auditory brain stem responses in the cat. I. Intracranial and extracranial recordings.. Electroencephalogr Clin Neurophysiol 1980; 48: 154-173.
10 Huang C. A comparative study of the brain stem auditory response in mammals.. Brain Res 1980; 184: 215-219.
11 Buchwald JS, Huang CM. Far field acoustic response: Origins in the cat.. Science 1975; 189: 382-384.
12 Trune DR, Mitchell C, Phillips DS. The relative importance of head size, gender and age on the auditory brainstem response.. Hear Res 1988; 32: 165-174.
13 Mitchell C, Phillips DS, Trune DR. Variables affecting the auditory brainstem response: Audiogram, age, gender, and head size.. Hear Res 1989; 40: 75-86.
14 Chambers RD, Matthies ML, Griffiths SK. Correlations between various measures of head size and auditory brainstem response latencies.. Hear Res 1989; 41: 179-188.
15 Pook HA, Steiss JE. Correlation of brain stem auditory-evoked responses with cranium size and body weight of dogs.. Am J Vet Res 1990; 51: 1779-1783.
16 Bodenhammer RD, Hunter JF, Luttgen PJ. Brain stem auditory-evoked responses in the dog.. Am J Vet Res 1985; 46: 1787-1792.
17 Munro KJ, Shiu JN, Cox CL. The effect of head size on the auditory brainstem response for two breeds of dog.. Br J Audiol 1997; 31: 309-314.
18 Antonelli AR, Bonfioli F, Nicolai P. The Relationship of head and brainstem size to main parameters of ABR in the developmental age and in adults.. Acta Otolaryngol 1988; 105: 587-590.
19 Strain GM, Tedford BL, Jackson RM. Postnatal development of the brainstem auditory-evoked potential in dogs.. Am J Vet Res 1991; 52: 410-415.
20 Latshaw WK. Veterinary developmental anatomy.. Toronto: BC Decker; 1987: 256-257 -269.